Research

Research watch · biological aging clocks · 2026 snapshot2026 aging-clock research is moving from one number toward organ, tissue and cell-type mapsMany clocksepigenetic, proteomic, clinical and cell-type models capture different signalsOrgan gapsdifferent systems can show different aging patterns in one personRisk signalprediction can be useful without proving that a clock measures aging itselfSurrogate gapresponsiveness to … Read more

Research watch · taurine and aging biomarkersThe taurine biomarker story changed when better longitudinal data arrived2023 claimcirculating taurine appeared to decline with age2025 updatelongitudinal data often found stable or higher levelsHuman variabilitywithin-person differences exceeded age trendsSeparate questionbiomarker validity is not supplement efficacyEvidence verdict: The influential 2023 Science paper suggested circulating taurine declines with age and … Read more

Research watch · creatine and agingNewer trials strengthen creatine’s muscle case, not a biological-aging claimMuscle evidencemodest lean-mass and lower-limb strength gainsTraining contextresistance exercise remains the stronger interventionCognitionpromising signals remain exploratoryLongevityno trial shows slower biological aging or longer life2026 verdict: The 2025–2026 evidence strengthens the case that creatine can modestly augment lean mass and lower-body strength … Read more

Research watch · 2026 systematic reviewNMN and NR show target engagement, not a settled anti-aging benefit113 studies33 human, 80 rodentBiochemical signaloral NMN and NR changed NAD-related metabolitesClinical uncertaintyhealthspan outcomes were mixed or often nullParenteral gapno eligible IV/IM NAD+ outcomes trialEvidence verdict: The 2026 systematic review supports biological activity from oral NMN and NR, but it … Read more

State of the field · evidence reviewed September 2026 Evidence summary The short answer Establishedhealthspan can be measured with clinical and functional outcomes Usefulaging clocks can stratify risk and track signals Unprovenno clock is a universal surrogate for lifespan Experimentalmost geroprotectors lack definitive human outcome evidence Bottom line: longevity science can increasingly measure biological aging … Read more